General Information

  • ID:  hor006462
  • Uniprot ID:  Q62949
  • Protein name:  Cortistatin-29
  • Gene name:  Cort
  • Organism:  Rattus norvegicus (Rat)
  • Family:  Somatostatin family
  • Source:  animal
  • Expression:  There is a transient increase in cortistatin-expressing cells in the second postnatal week in all cortical areas and in the dentate gyrus. A transient expression is observed in the hilar region at P16.|Interneurons in the cerebral cortex and hippocampus.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0001664 G protein-coupled receptor binding; GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; GO:0007218 neuropeptide signaling pathway; GO:0030334 regulation of cell migration; GO:0045187 regulation of circadian sleep/wake cycle, sleep
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  QERPPLQQPPHRDKKPCKNFFWKTFSSCK
  • Length:  29(84-112)
  • Propeptide:  MGGCSTRGKRPSALSLLLLLLLSGIAASALPLESGPTGQDSVQDATGGRRTGLLTFLAWWHEWASQDSSSTAFEGGTPELSKRQERPPLQQPPHRDKKPCKNFFWKTFSSCK
  • Signal peptide:  MGGCSTRGKRPSALSLLLLLLLSGIAA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Neuropeptide with neuronal depressant and sleep-modulating properties.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  17-28
  • Structure ID:  AF-Q62949-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006462_AF2.pdbhor006462_ESM.pdb

Physical Information

Mass: 405871 Formula: C161H245N47O41S2
Absent amino acids: AGIMVY Common amino acids: KP
pI: 10.62 Basic residues: 8
Polar residues: 6 Hydrophobic residues: 5
Hydrophobicity: -161.03 Boman Index: -9166
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 13.45
Instability Index: 6957.24 Extinction Coefficient cystines: 5625
Absorbance 280nm: 200.89

Literature

  • PubMed ID:  8622767
  • Title:  A cortical neuropeptide with neuronal depressant and sleep-modulating properties.